Gamma-glutamyltransferase (GGT1), active protein
Full Product Name
Gamma-glutamyltransferase (GGT), bovine kidney
Product synonym names
gamma-glutamyl transpeptidase; GGT
Product gene name
Active protein GGT1
OMIM: phenotype 612346
Host: Bovine kidney
Shape / Format
Powder, lyophilized from tris-acetate, pH 7.0
CAS number: 9046-27-9
C.E. number: 126.96.36.199
Appearance: Tan powder
Activity: 15 U / mg (Dimension® Clinical Chemistry System)
Definition of unit
One unit will catalyze the transfer of one micromole of the glutamyl moiety from gamma-glutamyl-3-carboxy-4-nitranilide to glycylglycine per minute at 37 ° C.
- 0.43 mg protein / mg solid (Coomassie)
- 0.59 mg protein / mg solid (A280)
- 36 U / mg protein (Coomassie)
- 26 U / mg protein (A280)
- CPK: <1.0%
- LDH: <1.0%
- SGOT / AST: <1.0%
- ALP: <0.2%
- SGPT / ALT: <0.01%
Ammonia: <0.1 umoles / mg
Driving: Handle as a potentially dangerous substance.
Preparation and storage
- Ships on blue ice.
- Store at -20 ° C. Protects from moisture.
Active protein note
Protein activity can be an ambiguous term. Please refer to the datasheet or consult Technical Support to determine the activity definition for this product.
Occasionally, small volumes of a vial (s) of active protein GGT1 may become trapped in the product vial seal during shipping and storage. If necessary, briefly centrifuge the vial in a benchtop centrifuge to dislodge any liquid on the lid of the container. Some products may need to be shipped with dry ice and an additional fee may apply for dry ice.
Related Product Information for Active protein GGT1
MyBioSource is the largest manufacturer of bovine kidney gamma-glutamyl transpeptidase, gamma-glutamyl transferase (GGT / GGTP). 100,000 km single batch sizes. Custom preparations, technical support, bulk quantities, and aliquots available.
Detection of liver disease, obstructive jaundice, cholangitis, infectious hepatitis, and cholecystitis. The gamma-glutamyltransferase (gGT / GGTP) test is used to detect diseases of the liver, bile ducts, and kidneys; and to differentiate liver or bile duct (hepatobiliary) disorders from bone diseases.
Our bovine kidney gamma-glutamyl transpeptidase (gGT / GGTP) is used in multi-analyte clinical chemistry calibrators and controls for leading IVD manufacturers around the world. We can custom purify GGT from the bovine kidneys to meet your specific application.
NCBI Summary for GGT1
The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is made up of a heavy chain and a light chain, which are derived from a single precursor protein.
It is expressed in tissues involved in absorption and secretion and can contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are several related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, January 2014]
UniProt feedback for GGT1
GGT1: initiates the breakdown of extracellular glutathione (GSH), provides cells with a local cysteine supply and contributes to maintaining the level of intracellular GSH. It is part of the cellular antioxidant defense mechanism. It catalyzes the transfer of the glutamyl moiety of glutathione to amino acids.